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The tablets shall be taken with liquidand should not be crushed or chewedViramune may be taken with or without food.

Boceprevir is partly metabolized by CYP3A4/5Co-administration of boceprevir with medicines that induce or inhibit CYP3A4/5 could increase or decrease exposurePlasma trough concentrations of boceprevir were decreased when administered with an NNRTI with a similar metabolic pathway as nevirapineThe clinical outcome of this observed reduction of boceprevir trough concentrations has not been directly assessed.

Viramune is indicated in combination with other anti-retroviral medicinal products for the treatment of HIV-1 infected adultsadolescentsand children of any agesee section 4.2

Hormonal methods of birth control other than Depo-medroxyprogesterone acetateDMPAshould not be used as the sole method of contraception in women taking Viramunesince nevirapine might lower the plasma concentrations of these medicinal productsFor this reasonand to reduce the risk of HIV transmissionbarrier contraceptione.gcondomsis recommendedAdditionallywhen postmenopausal hormone therapy is used during administration of nevirapineits therapeutic effect should be monitored.

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